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A Convenient Synthesis of N-Methoxy-N-Methylamides from Carboxylic Acids |
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| Authors: | Mukund P. Sibi Chad C. Stessman Jeffrey A. Schultz James W. Christensen Jianliang Lu Mali Marvin |
| Affiliation: | Department of Chemistry , North Dakota State University Fargo , ND, 58105 |
| Abstract: | Carboxylic acids can be converted to their corresponding N-methoxy-N-methylamides in high yields using 2-chloro-1-methylpyridinium iodide as the coupling agent. The reaction proceeds without racemization when chiral carboxylic acids are used as the starting material. |
| Keywords: | Sodium bromate Ion exchange catalysis Alkylarenes Alcohols Solvent free Oxidation |