Synthetic Chemistry SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue , Harlow, Essex, CM19 5AW
Abstract:
The one-pot condensation of N-methylhomoveratrylamine with acrolein followed by in situ reductive amination with 3,4-dimethoxyaniline to give an unsymmetrical propane 1,3-diamine in excellent yield is described.