A Simple Synthesis of the Natural 2,5-Dialkylresorcinol Free Radical Scavenger Antioxidant: Resorstatin |
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| Authors: | Sébastien Combes Jean-Pierre Finet |
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| Institution: | Laboratoire Chimie, Biologie et Radicaux Libres , UMR - CNRS 6517 Faculté des Sciences Saint-Jérome, 13397, Marseille, Cedex 20, France |
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| Abstract: | 3,5-Dimethoxybenzoic acid 3 has been transformed into olivetol dimethyl ether 6 in three steps in 79% yield. Directed ortho-metallation-alkylation of 6, followed by boron tribromide demethylation resulted in a simple and inexpensive synthesis of resorstatin, in 70% overall yield from 3. |
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