Catalytic Hydrogenation of Chiral 2-(2-Furyl)-3,4-dimethyl-5-phenyloxazolidine |
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| Authors: | Felix Polyak Tatiana Dorofeeva Gunar Zelchan |
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| Institution: | 1. Latvian Institute of Organic Synthesis , LV-1006, Riga, LATVIA;2. Department of Chemistry , Technion–Israel Institute of Technology , Haifa, 32000, Israel;3. Latvian Institute of Organic Synthesis , LV-1006, Riga, LATVIA |
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| Abstract: | Reduction of chiral 2-(2-furyl)-3,4-dimethyl-5-phenyloxazo-lidines-1,3 by H2/Raney nickel proceeds simultaneously as hydrogenation of the furan ring and opening of the oxazolidine ring on C2-O bond. Diastere-oselectivity in the first reaction was established as ca 40% and 80% depending on the configuration of the oxazolidine 1 and 2. |
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