An Efficient and General Procedure for the Cross-Coupling of Trimethylsilylacetylene and Vinylic,Aromatic or Heteroaromatic Bromides |
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| Authors: | L Brandsma H GM van den Heuvel H D Verkruijsse |
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| Institution: | Department of Synthetic Organic Chemistry , Debye Institute, University of Utrecht , Padualaan 8, 3584, CH, Utrecht, The Netherlands |
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| Abstract: | Coupling reactions of trimethylsilylacetylene and vinylic, aromatic or heteroaromatic bromides can be carried out in very short time and with excellent yield using piperidine as a solvent and very small amounts of tetrakis(triphenylphosphine)palladium and copper(I)iodide (0.1 to 0.3 g on 100 mmol scale) as catalysts. |
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