Preparation of 5-(1-Aminocyclohexyl)-2(1H)-Pyridinones Via the Ritter Reaction |
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| Authors: | David M Fink Richard C Effland |
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| Institution: | Chemical Research Department Neuroscience Strategic Business Unit , Hoechst-Roussel Pharmaceuticals Inc , P.O. Box 2500, Somerville, NJ, 08876 |
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| Abstract: | A series of 5-(1-aminocyclohexyl)-2(1H)-pyridinones was prepared in 16-32% yield. The key step is a Ritter reaction of the analogous alcohols. The results reported demonstrate the difference in reactivity between the closely related 2-alkoxy-pyridines and 2 (1H)-pyridinones. |
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