A Stereospecific Route to 6-Substituted-7-Azabicyclo[3.2.1]Oct-2-Ones |
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| Authors: | Grant R. Krow Donald A. Shaw Steven Szczepanski Harri G. Ramjit |
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| Affiliation: | 1. Department of Chemistry , Temple University , Philadelphia, PA, 19122;2. Merck Sharp and Dohme Research Laboratories , West Point, PA, 19486 |
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| Abstract: | N-carbethoxy-3-exo- or 3-endo-substituted-2-azabicyclo-[2.2.2]oct-5-enes 1 provide the title compounds 2 by a stercospecific route involving bromohydrin formation, reductive dehalogenation and oxidation. |
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