An Improved Synthesis of 5,7-Dimethoxy-4-methylphthalide,A Key Intermediate in the Synthesis of Mycophenolic Acid |
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| Authors: | Gergely M Makara Kevin Klubek Wayne K Anderson |
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| Institution: | Department of Medicinal Chemistry , School of Pharmacy, State University of New York at Buffalo , Buffalo, NY, 14260 |
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| Abstract: | An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phthalide 3 in 55% overall yield. |
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