Convenient and Short Route to a Key Intermediate in the Synthesis of Forskolin |
| |
| Authors: | José A. Bacigaluppo María I. Colombo Juan Zinczuk Silvia N. Huber Mirta P. Mischne Edmundo A. Rúveda |
| |
| Affiliation: | Instituto de Química Orgánica de Síntesis (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas , Casilla de Correo 991, 2000, Rosario, Argentina |
| |
| Abstract: | The intermediate 2, previously used in several synthetic sequences toward forskolin (1), has been synthesized from enone 3. The key step in the sequence is the 1,3-oxidative rearrangement of the tertiary alcohol 5, which allowed the easy introduction of the keto group at C-6 of 2. |
| |
| Keywords: | |
|
|
