An Improved Method for γ-Carboxylation of β-Diketones. Synthesis of 4-Alkyl-3,5-Dioxohexanoic Acids and 5-Alkyl Derivatives of Triacetic Acid Lactone |
| |
Authors: | Jordi Cervelló Jorge Marquet Marcial Moreno-mañas |
| |
Affiliation: | Department of Chemistry , Universitat Autònoma de Barcelona , Bellaterra, 08193, Barcelona, Spain |
| |
Abstract: | γ-Carboxylation of β-diketones, 1, can be improved using samples containing 100% of ketoenol tautomers, 3, prepared by mild hydrolysis of the corresponding copper(II) complexes 2. Cyclization of the so formed 4-alkyl-3,5-dioxohexanoic acids, 4, affords 5-alkyl-4-hydroxy-6-methyl-2-pyrones, 5. |
| |
Keywords: | |
|
|