A Benzylation Study of 2,3-Dichloronaphthazarin |
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| Authors: | C C Cheng HeXi Chang Martha Morton David Vander Velde |
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| Institution: | 1. Drug Development Laboratory, Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City, KS, 66160-7419;2. NMR Laboratory, Department of Medicinal Chemistry , University of Kansas , Lawrence, KS, 66045 |
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| Abstract: | Depending on different reaction time and temperature employed, benzylation of 2,3-dichloronaphthazarin (I) using silver oxide as the catalyst can form either exclusively 5,8-dibenzyloxy-6,7-dichloronaphthalene-1,4-dione (II), or exclusively 5-benzyloxy-2,3-dichloro-8-hydroxynaphthalene-1,4-dione (IV); or a mixture of II and 5,8-dibenzyloxy-2,3-dichloronaphthalene-1,4-dione (III). Structures of these compounds were identified by nmr analysis. |
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