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The Synthesis of 4-Amino-2-methyl-3-(1-oxo) Pent-4-ynyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine |
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| Authors: | David Bolton Amanda Johns Mervyn Thompson |
| Institution: | SmithKline Beecham Pharmaceuticals , The Pinnacles , Harlow, Essex CM19, 5AD, UK |
| Abstract: | The synthesis of ketone 1 from the ethyl ester of 4-amino-2-methyl-5,6,7,8-tetrahydrobenzob]thieno2,3-b]pyridine-3-carboxylic acid using β-ketosulfone methodology is described. |
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