| 一种新型的莪术醇衍生物的波谱学分析 |
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| 引用本文： | 曹雪,李悦青,刘季红,赵伟杰. 一种新型的莪术醇衍生物的波谱学分析[J]. 波谱学杂志, 2011, 28(3): 399-406 |
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| 作者姓名： | 曹雪 李悦青 刘季红 赵伟杰 |
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| 作者单位： | 大连理工大学 化工与环境生命学部 制药科学与技术学院，辽宁 大连 116024 |
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| 基金项目： | 中央高校基本科研业务费资助项目 |
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| 摘 要： | 莪术醇进行环外双键断裂氧化和酸催化氧桥开环加成2步反应后，经硅胶柱层析分离，得到一种新型的莪术醇衍生物（2）. 应用1D NMR和2D NMR测试了化合物2的1H NMR、13C NMR、1H-1H COSY、gHSQC、gHMBC，对化合物2的1H和13C化学位移进行了全归属，结合其红外光谱和质谱，推得化合物2为8-羟基-12-异丙基-2-甲基-三环[6.2.2.01,5]十二烷-10-氧杂-6,9-二酮，并比较了莪术醇，莪术醇双键断裂氧化产物(化合物1)，化合物2的1H NMR、13C NMR数据变化.
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| 关 键 词： | 核磁共振(NMR) 归属 2D NMR 莪术醇衍生物 |
| 收稿时间： | 2010-01-19 |
NMR Characterization of a Novel Curcumol Derivative |
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| CAO Xue,LI Yue-qing,LIU Ji-hong,ZHAO Wei-jie. NMR Characterization of a Novel Curcumol Derivative[J]. Chinese Journal of Magnetic Resonance, 2011, 28(3): 399-406 |
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| Authors: | CAO Xue LI Yue-qing LIU Ji-hong ZHAO Wei-jie |
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| Affiliation: | School of Pharmaceutical Science and Technology, Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China |
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| Abstract: | The structure of curcumol was modified via a two-step reaction: exocyclic double bond oxidation and oxygen bridges acylation within the seven-membered ring.The reaction product was purified by silica gel column chromatography.Compound 2 was characterized by IR,ESI-MS,1H NMR,13C NMR and 2D NMR(i.e.,gCOSY,gHSQC and gHMBC) techniques.The 1H and 13C NMR signals of compound 2 were assigned.Its structure was elucidated as 8-hydroxyl-12-isopropyl-2-methyl-tricyclo [6.2.2.01,5] dodecane-10-oxa-6,9-dione. |
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| Keywords: | NMR chemical shift 2D NMR curcumol derivatives |
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