Synthesis of β‐Chlorohydrins in Water |
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| Authors: | Biswanath Das Katta Venkateswarlu Maddeboina Krishnaiah |
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| Institution: | 1. Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500?007, India, (phone: +?91‐40‐7193434;2. fax: +?91‐40‐7160512) |
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| Abstract: | 2,4,6‐Trichloro‐1,3,5‐triazine (TCT, cyanuric chloride) was found to mediate the regio‐ and stereoselective ring opening of epoxides in H2O in the presence of morpholine at room temperature to afford the corresponding β‐chlorohydrins in excellent yields (Table). The transformation is very simple, fast, efficient, and ecologically beneficial. |
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| Keywords: | Epoxides Ring‐opening reactions Cyanuric chloride Morpholine β ‐Chlorohydrins 1 3 5‐Triazine 2 4 6‐trichloro‐ |
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