Chemoselective C(sp3)?H Bond Activation for the Preparation of Condensed N‐Heterocycles |
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| Authors: | Hongjun Ren Zhuo Li Paul Knochel Prof?Dr |
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| Institution: | Ludwig‐Maximilians‐Universit?t München, Department Chemie und Biochemie, Butenandtstrasse 5‐13, Haus F, 81377 München, Germany, Fax: (+49)?089‐21‐80‐776‐80 |
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| Abstract: | Condensed N‐heterocycles were prepared by using C? H activation reactions catalyzed by Pd(OAc)2 (5 mol %) and (p‐tolyl)3P (10 mol %). The key step of these ring closures is chemoselective intramolecular C? H activation of the methyl group at position 2 of the pyrrole ring. Functionalized 9H‐pyrrolo1,2‐a]indoles and pyrrolo1,2‐f]phenanthridine derivatives were prepared in good yields. The preparation of some complex N‐heterocycles by using successive reactions is also described. |
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| Keywords: | C?H activation N‐heterocycles palladium pyrroles successive reactions |
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