Total Synthesis of Lactacystin and Salinosporamide A |
| |
Authors: | Masakatsu Shibasaki Prof. Dr. Motomu Kanai Dr. Nobuhisa Fukuda |
| |
Affiliation: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113‐0033, Japan, Fax: (+81)?3‐5684‐5206 |
| |
Abstract: | Lactacystin and salinosporamide A are fascinating molecules with regard to both their chemical structures and biological activities. These naturally occurring compounds are potent and selective proteasome inhibitors. The molecular structures are characterized by their densely functionalized γ‐lactam cores. The structure and biological properties of these two compounds are attracting the attention of many chemists as challenging synthetic targets. We discuss their synthetic strategies in this review. |
| |
Keywords: | asymmetric synthesis lactacystin lactams natural products salinosporamide A |
|