Protective Effect of Cudrania tricuspidata Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway |
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Authors: | Jitendra Shrestha Dong-Jae Baek Yoon-Sin Oh Sam-Seok Cho Sung-Hwan Ki Eun-Young Park |
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Affiliation: | 1.College of Pharmacy, Mokpo National University, Jeonnam 58554, Korea; (J.S.); (D.-J.B.);2.Department of Food and Nutrition, Eulji University, Seongnam 13135, Korea;3.College of Pharmacy, Chosun University, Gwangju 61452, Korea; |
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Abstract: | Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world’s population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic target has not been developed yet. Previously, there have been reports on the benefits of Cudrania tricuspidata (CT) for treating obesity and diabetes via regulation of metabolic processes, such as lipogenesis, lipolysis, and inflammation. In this study, we investigated the ameliorative effect of orally administered 0.25% and 0.5% (w/w) CT mixed with high-fat diet (HFD) to C57BL/6J mice for 7 weeks. It was found that body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels were significantly reduced after CT treatment. In CT-treated HFD-fed mice, the mRNA expression levels of hepatic lipogenic and inflammatory cytokine-related genes were markedly reduced, whereas the expression level of epididymal lipogenic genes was increased. The mRNA expression level of beta-oxidation and Nrf-2/HO-1 genes significantly increased in CT-treated obese mice livers. We propose that CT alleviates hepatic steatosis by reducing oxidative stress and inflammation. |
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Keywords: | nonalcoholic fatty liver disease Cudrania tricuspidata antioxidant nuclear factor erythroid 2 like 2 |
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