Silanol as a removable directing group for the Pd(II)-catalyzed direct olefination of arenes |
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| Authors: | Wang Cong Ge Haibo |
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| Institution: | Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford St. Indianapolis, IN 46202, USA. |
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| Abstract: | Need some direction? Silanol was developed as a directing group for the Pd(II)-catalyzed oxidative Heck-type reaction of arenes. A one-pot C-H activation/desilylation process of benzyldiisopropylsilanol was also demonstrated, providing a powerful approach for the synthesis of ortho-alkenyl-substituted alkylarenes. Considering the easily attachable and readily removable properties of the silanol group, this reaction will find broad synthetic applications. |
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| Keywords: | arenes directing groups olefination palladium silanols |
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