| 尿苷环甘油磷脂缀合物的合成 |
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| 引用本文： | 张成祥,张中标.尿苷环甘油磷脂缀合物的合成[J].高等学校化学学报,1997,18(11):1809-1813. |
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| 作者姓名： | 张成祥 张中标 |
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| 作者单位： | 南开大学元素有机化学研究所!天津，300071 |
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| 摘 要： | 报道尿苷２－烷基（酰基）－１，３－甘油硫代环磷酸酯的合成，用碘活化的六乙基亚磷酰三胺作为磷酸化试剂，分离得到了硫代环磷酸酯的两个顺反异构体。初步生物活性测试结果表明，该化合物具有一定的细胞毒性。
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| 关 键 词： | 尿苷 环甘油磷脂 硫代磷酸酯 核苷 缀合物 |
Synthesis of Glycerophospholipid Conjugates of Uridine |
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| ZHANG Cheng-Xiang, ZHANG Zhong-Biao, TANG Chu-Chi,CHEN Huan-Ming, CHI Guo-Chen, CHEN Ru-Yu.Synthesis of Glycerophospholipid Conjugates of Uridine[J].Chemical Research In Chinese Universities,1997,18(11):1809-1813. |
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| Authors: | ZHANG Cheng-Xiang ZHANG Zhong-Biao TANG Chu-Chi CHEN Huan-Ming CHI Guo-Chen CHEN Ru-Yu |
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| Abstract: | New structural liponucleoside prodrugs were prepared in which uridine wascovalently attached to cyclic phospholipids.The strategy for the synthesis used hexaethylphosphorous triamide, activated by a catalytic amount of iodine, as the phosphorylating reagentin a one-pot reaction resulting in a number of phospholipid-uridine conjugates. The celltoxicity experiments show that the compounds have certain selective antitumor activities. |
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| Keywords: | Uridine Cyclicglycerophospholipid Thiophosphate Cytotoxicity |
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