| Kinetic Resolution of 2-Chloro-1-（3,4-dichlorophenyl）ethanol by Lipase-Catalyzed Transesterification |
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| 引用本文： | 王明慧 李亚丰 刘永军 张书圣. Kinetic Resolution of 2-Chloro-1-（3,4-dichlorophenyl）ethanol by Lipase-Catalyzed Transesterification[J]. 中国化学, 2007, 25(11): 1700-1703. DOI: 10.1002/cjoc.200790314 |
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| 作者姓名： | 王明慧 李亚丰 刘永军 张书圣 |
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| 作者单位： | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China |
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| 基金项目： | Project supported by the Doctoral Foundation of Qingdao University of Science and Technology （No. 0022266）, the Program for New Century Excellent Talents in Universities （No. NCET-04-0649）, and the Natural Science Foundation of Shandong Province （No. Z2006B01）. |
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| 摘 要： | Kinetic resolution of racemic 2-chloro-1-（3,4-dichlorophenyl）ethanol was performed by free Alcaligene sp. lipase-catalyzed irreversible transesterification affording the （R）-isomer with ≥95% ee and the （S）-isomer with ≥90% ee. The activity of lipase Alcaligene sp. strongly depends on the basicity of the reaction system, and an organic base such as triethylamine can enhance the activity of the lipase and enantioselectivity markedly.
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| 关 键 词： | 动态分析 酯交换 乙醇 脂肪酶催化分析 |
| 修稿时间： | 2007-03-06 |
Kinetic Resolution of 2-Chloro-1-(3,4-dichlorophenyl)ethanol by Lipase-Catalyzed Transesterification |
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| WANG, Ming-Hui LI, Ya-Feng LIU, Yong-Jun ZHANG, Shu-Sheng. Kinetic Resolution of 2-Chloro-1-(3,4-dichlorophenyl)ethanol by Lipase-Catalyzed Transesterification[J]. Chinese Journal of Chemistry, 2007, 25(11): 1700-1703. DOI: 10.1002/cjoc.200790314 |
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| Authors: | WANG Ming-Hui LI Ya-Feng LIU Yong-Jun ZHANG Shu-Sheng |
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| Affiliation: | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China |
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| Abstract: | Kinetic resolution of racemic 2-chloro-1-(3,4-dichlorophenyl)ethanol was performed by free Alcaligene sp. lipase-catalyzed irreversible transesterification affording the (R)-isomer with ≧ 95% ee and the (S)-isomer with ≧ 90% ee. The activity of lipase Alcaligene sp. strongly depends on the basicity of the reaction system, and an organic base such as triethylamine can enhance the activity of the lipase and enantioselectivity markedly. |
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| Keywords: | 2-chloro-1-(3,4-dichlorophenyl)ethanol lipase-catalyzed resolution chiral alcohol transesterification reaction |
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