| Enantioselective Alkynylation of Ketones Promoted by β-Sulfonamide Alcohol-Titanium Complexes |
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| 引用本文： | 倪明,周益峰,陈超,许江珂,王锐.Enantioselective Alkynylation of Ketones Promoted by β-Sulfonamide Alcohol-Titanium Complexes[J].中国化学,2007,25(5):694-697. |
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| 作者姓名： | 倪明 周益峰 陈超 许江珂 王锐 |
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| 作者单位： | [1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China [2]Department of Biology, Hubei Normal University, Huangshi, Hubei 435002, China [3]State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China |
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| 基金项目： | Project suported by the National Natural Science Foundation of China （Nos. 20372028, 20472026, 20525206, 20021001） and the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China. |
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| 摘 要： | A readily available β-sulfonamide alcohol-titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated simple ketones under very mild conditions. And the corresponding chiral tertiary propargylic alcohols were obtained with enantiomeric excesses of up to 86%, which provided a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.
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| 关 键 词： | 酮 对映体选择性烷基化 β-磺胺醇 钛配合物 |
| 修稿时间： | 2006-07-182006-11-03 |
Enantioselective Alkynylation of Ketones Promoted by β‐Sulfonamide Alcohol‐Titanium Complexes |
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| NI, Ming ZHOU, Yi-Feng CHEN, Chao XU, Jiang-Ke WANG, Rui.Enantioselective Alkynylation of Ketones Promoted by β‐Sulfonamide Alcohol‐Titanium Complexes[J].Chinese Journal of Chemistry,2007,25(5):694-697. |
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| Authors: | NI Ming ZHOU Yi-Feng CHEN Chao XU Jiang-Ke WANG Rui |
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| Institution: | a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China b Department of Biology, Hubei Normal University, Huangshi, Hubei 435002, China c State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China |
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| Abstract: | A readily available β‐sulfonamide alcohol‐titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated simple ketones under very mild conditions. And the corresponding chiral tertiary propargylic alcohols were obtained with enantiomeric excesses of up to 86%, which provided a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols. |
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| Keywords: | ketone asymmetric alkynylation β‐sulfonamide alcohol catalysis |
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