| Inhibition of Homo-coupling of Arylboronic Acids in Ligand Free Pd（ll）-Catalyzed Suzuki Reaction |
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| 引用本文： | 陶晓春,张月平,何天雄,沈冬.Inhibition of Homo-coupling of Arylboronic Acids in Ligand Free Pd（ll）-Catalyzed Suzuki Reaction[J].中国化学,2007,25(9):1326-1329. |
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| 作者姓名： | 陶晓春 张月平 何天雄 沈冬 |
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| 作者单位： | [1]Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237, China [2]Laboratory of Chemical Physics, East China University of Science and Technology, Shanghai 200237, China |
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| 基金项目： | Project supported by Ministry of Education, of the People＇s Republic of China and East China University of Science and Technology. |
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| 摘 要： | A series of solvents were examined for the ligand free Pd（II）-catalyzed Suzuki reaction of 4-bromotoluene with phenylboronic acid. It was found that the PdCl2/i-PrOH system could efficiently inhibit the homo-coupling of phenylboronic acid and give a cross-coupling product in high yields. The substrates with a wide variety of functional groups were tolerated in the system. A possible mechanism for this system was proposed.
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| 关 键 词： | 抑制作用 配位体 异丙醇 芳基溴 |
| 修稿时间： | 2006-12-24 |
Inhibition of Homo‐coupling of Arylboronic Acids in Ligand Free Pd(II)‐Catalyzed Suzuki Reaction |
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| TAO Xiao-Chuna, ZHANG Yue-Pinga, HE Tian-Xiong, SHEN Dong.Inhibition of Homo‐coupling of Arylboronic Acids in Ligand Free Pd(II)‐Catalyzed Suzuki Reaction[J].Chinese Journal of Chemistry,2007,25(9):1326-1329. |
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| Authors: | TAO Xiao-Chuna ZHANG Yue-Pinga HE Tian-Xiong SHEN Dong |
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| Institution: | 1.Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237, China ;2.Laboratory of Chemical Physics, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | A series of solvents were examined for the ligand free Pd(II)‐catalyzed Suzuki reaction of 4‐bromotoluene with phenylboronic acid. It was found that the PdCl2/i‐PrOH system could efficiently inhibit the homo‐coupling of phenylboronic acid and give a cross‐coupling product in high yields. The substrates with a wide variety of functional groups were tolerated in the system. A possible mechanism for this system was proposed. |
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| Keywords: | homo-coupling cross-coupling isopropanol aryl bromide arylboronic acid |
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