| Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2＇,1＇：5,1]pyrazolo[4,3-d]pyrimidin-4-one Derivatives |
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| 引用本文： | 田广辉,夏广新,金薇西,陈新建,赖顺安,韦亚兵,嵇汝运,沈敬山.Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2＇,1＇：5,1]pyrazolo[4,3-d]pyrimidin-4-one Derivatives[J].中国化学,2007,25(2):241-245. |
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| 作者姓名： | 田广辉 夏广新 金薇西 陈新建 赖顺安 韦亚兵 嵇汝运 沈敬山 |
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| 作者单位： | [1]Shanghai Institute ofMateria Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China [2]Nanjing University of Technology, Nanjing, Jiangsu 210009, China [3]Topharman Shanghai Co., Ltd., Shanghai 201209, China |
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| 摘 要： |
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| 关 键 词： | 衍生物 高分子化学 合成方法 化合物 化学活性 |
| 修稿时间： | 2006-05-222006-10-10 |
Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2′,1′:5,1]pyrazolo[4,3‐d]pyrimidin‐4‐one Derivatives |
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| TIAN, Guang-Hui XIA, Guang-Xin JIN, Wei-Xi CHEN, Xin-Jian LAI, Shun-An WEI, Ya-Bing JI, Ru-Yun SHEN, Jing-Shan.Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2′,1′:5,1]pyrazolo[4,3‐d]pyrimidin‐4‐one Derivatives[J].Chinese Journal of Chemistry,2007,25(2):241-245. |
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| Authors: | TIAN Guang-Hui XIA Guang-Xin JIN Wei-Xi CHEN Xin-Jian LAI Shun-An WEI Ya-Bing JI Ru-Yun SHEN Jing-Shan |
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| Institution: | 1 Shanghai Institute ofMateria Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 201203, China ;2 Nanjing University of Technology, Nanfing, Jiangsu 210009, China ;3 Topharman Shanghai Co., Ltd., Shanghai 201209, China |
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| Abstract: | Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil. |
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| Keywords: | pyridopyrazolopyrimidinone PDE5 inhibitor sildenafil |
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