| Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes |
| |
| 引用本文： | 古琴 乐学义 林庆斌 廖升荣 马雪丹 冯小龙. Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes[J]. 中国化学, 2007, 25(6): 791-796. DOI: 10.1002/cjoc.200790145 |
| |
| 作者姓名： | 古琴 乐学义 林庆斌 廖升荣 马雪丹 冯小龙 |
| |
| 作者单位： | [1]Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, China [2]Center of Analysis and Measurement, Zhongshan University, Guangzhou, Guangdong 510275, China |
| |
| 基金项目： | Project supported by the Natural Science Foundation of Guangdong Province （No. 04105986）. |
| |
| 摘 要： | Four new ternary complexes： [Cu（IP）（L-Val）（H2O）]ClO4·1.5H2O（1）, [Cu（IP）（L-Leu）（H2O）]ClO4（2）, [Cu（IP）（L-Tyr）（H2O）]ClO4·H2O（3） and [Cu（IP）（L-Trp）（H2O）]ClO4·1.5H2O（4） have been synthesized and character/zed by elementa/analysis, molar conductivity, infrared absorption spectroscopy, electronic absorption spectroscopy and cyclic voltammetry, where IP=imidazo[4,5-f][1,10] phenanthroline, L-Val=L-valinate, L-Leu=L-leucinate, L-Tyr=L-tyrosinate and L-Trp=L-tryptophanate. Complex 3 was structurally characterized by X-ray diffraction method, which crystallizes in orthorhornbic space group P21212 in a unit cell of dimensions a=3.0567（4） nm, b=0.74079（9） nm, c= 1.06198（13） nm, V=2.4047（5） nm^3, Z=4,μ=0.1084 cm^-1. The SOD-like activities of catalytic disrnutation of superoxide anions （O2^-· ） by the complexes were determined by means of modified nitroblue tetrazolium （NBT） photoreduction. The IC50 values of complexes 1, 2, 3 and 4 are 0.072, 0.147, 0.429 and 0.264 μmol·L^-1, respectively
|
| 关 键 词： | 三元铜配合物 L-氨基酸 超氧化物岐化酶 合成 表征 酶活性 |
| 修稿时间： | 2006-06-232007-03-07 |
Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes |
| |
| GU, Qin LE, Xue-Yi LIN, Qing-Bin LIAO, Sheng-Rong MA, Xue-Dan FENG, Xiao-Long. Synthesis,Characterization and SOD Activities of IP-copper（Ⅱ）-L-amino Acid Complexes[J]. Chinese Journal of Chemistry, 2007, 25(6): 791-796. DOI: 10.1002/cjoc.200790145 |
| |
| Authors: | GU Qin LE Xue-Yi LIN Qing-Bin LIAO Sheng-Rong MA Xue-Dan FENG Xiao-Long |
| |
| Affiliation: | a Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, China; b Center of Analysis and Measurement, Zhongshan University, Guangzhou, Guangdong 510275, China |
| |
| Abstract: | Four new ternary complexes: [Cu(IP)(L‐Val)(H2O)]ClO4·1.5H2O ( 1 ), [Cu(IP)(L‐Leu)(H2O)]ClO4 ( 2 ), [Cu(IP)(L‐Tyr)(H2O)]ClO4·H2O ( 3 ) and [Cu(IP)(L‐Trp)(H2O)]ClO4·1.5H2O ( 4 ) have been synthesized and characterized by elemental analysis, molar conductivity, infrared absorption spectroscopy, electronic absorption spectroscopy and cyclic voltammetry, where IP=imidazo[4,5‐f][1,10] phenanthroline, L‐Val=L‐valinate, L‐Leu=L‐leucinate, L‐Tyr=L‐tyrosinate and L‐Trp=L‐tryptophanate. Complex 3 was structurally characterized by X‐ray diffraction method, which crystallizes in orthorhombic space group P21212 in a unit cell of dimensions a=3.0567(4) nm, b=0.74079(9) nm, c=1.06198(13) nm, V=2.4047(5) nm3, Z=4, μ=0.1084 cm?1. The SOD‐like activities of catalytic dismutation of superoxide anions (O?2) by the complexes were determined by means of modified nitroblue tetrazolium (NBT) photoreduction. The IC50 values of complexes 1 , 2 , 3 and 4 are 0.072, 0.147, 0.429 and 0.264 µmol·L?1, respectively. |
| |
| Keywords: | ternary copper（Ⅱ） complex superoxide dismutase （SOD） SOD-like activity |
| 本文献已被 维普 等数据库收录！ |
|
