| Synthesis,Structure Analysis,and Antitumor Activity of （R）-2,4-Dioxo-5-fluoro-l-[1-（methoxycarbonyl） Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine |
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| 引用本文： | 袁继新 蔡晓庆 陈迪妹 胡茂林. Synthesis,Structure Analysis,and Antitumor Activity of （R）-2,4-Dioxo-5-fluoro-l-[1-（methoxycarbonyl） Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine[J]. 中国化学, 2007, 25(3): 417-421. DOI: 10.1002/cjoc.200790080 |
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| 作者姓名： | 袁继新 蔡晓庆 陈迪妹 胡茂林 |
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| 作者单位： | College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325027, China |
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| 基金项目： | Project supported by the Natural Science Foundation of Zhejiang Province （No. Y405078） and the National Natural Science Foundation of China （No. 20571057）. |
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| 摘 要： | A new dipeptide compound, （R）-2,4-dioxo-5-fluoro-1-[1-（methoxycarbonyl） ethylaminocarbonylmethyl]-1,2,3, 4-tetrahydropyrimidine （5-FUAPM）, has been synthesized and identified by means of elemental analysis, IR, ^1H NMR and ^13C NMR spectra. The single crystal of compound 5-FUAPMoDMF was also obtained and characterized by DSC-TGA techniques. The crystal belongs to orthorhombic space group P212121 with the cell parameters： a= 0.4740（7） nm, b= 1.923（3） nm, c= 1.9229 nm, a=β=y=90°, V= 1.753 nm^3, Z=4, Dc= 1.312 g/cm^3, Mr=346.32, F（000）=728 and u=0.111 mm^-1. The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5-FUAPM has certain antitumor activities.
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| 关 键 词： | 5-FUAPM 合成 结构分析 热分析 抗肿瘤活性 |
| 修稿时间： | 2006-09-132006-12-10 |
Synthesis,Structure Analysis,and Antitumor Activity of （R）-2,4-Dioxo-5-fluoro-l-[1-（methoxycarbonyl） Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine |
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| YUAN Ji-Xin, CAI Xiao-Qing, CHEN Di-Mei, HU Mao-Lin. Synthesis,Structure Analysis,and Antitumor Activity of （R）-2,4-Dioxo-5-fluoro-l-[1-（methoxycarbonyl） Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine[J]. Chinese Journal of Chemistry, 2007, 25(3): 417-421. DOI: 10.1002/cjoc.200790080 |
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| Authors: | YUAN Ji-Xin CAI Xiao-Qing CHEN Di-Mei HU Mao-Lin |
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| Affiliation: | College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325027, China |
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| Abstract: | A new dipeptide compound, (R)‐2,4‐dioxo‐5‐fluoro‐1‐[1‐(methoxycarbonyl) ethylaminocarbonylmethyl]‐1,2,3, 4‐tetrahydropyrimidine (5‐FUAPM), has been synthesized and identified by means of elemental analysis, IR, 1H NMR and 13C NMR spectra. The single crystal of compound 5‐FUAPM·DMF was also obtained and characterized by DSC‐TGA techniques. The crystal belongs to orthorhombic space group P2121 21 with the cell parameters: a=0.4740(7) nm, b=1.923(3) nm, c=1.9229 nm, α=β=γ=90°, V=1.753 nm3, Z=4, Dc=1.312 g/cm3, Mr=346.32, F(000) =728 and μ=0.111 mm?1. The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5‐FUAPM has certain antitumor activities. |
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| Keywords: | 5-FUAPM synthesis structure thermal analysis antitumor activity |
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