| Synthesis of （S）-2-Ethoxy-3-Phenylpropanoic Acid Derivatives and Their Insulin-Sensitizing Activity |
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| 引用本文： | 吴英华 夏彬. Synthesis of （S）-2-Ethoxy-3-Phenylpropanoic Acid Derivatives and Their Insulin-Sensitizing Activity[J]. 中国化学, 2007, 25(3): 265-267. DOI: 10.1002/cjoc.200790052 |
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| 作者姓名： | 吴英华 夏彬 |
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| 作者单位： | [1]Department of Pharmaceuticals, Huaihua Medical College, Huaihua, Hunan 418000, China [2]College of Chemistry and Environmental Science, Guizhou University for Nationalities, Guiyang, Guizhou 550025, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 30500390） and the Science Foundation of the Hunan Education Department （No. 06B075）. |
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| 摘 要： | A series of （S）-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b, 1d, 1e and 1f exhibited more potent insulin-sensitizing activity than rosiglitazone.
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| 关 键 词： | （S）-2-乙氧基-3-苯基丙酸衍生物 合成 胰岛素敏化活性 2型糖尿病 |
| 修稿时间： | 2006-06-122006-12-05 |
Synthesis of (S)‐2‐Ethoxy‐3‐Phenylpropanoic Acid Derivatives and Their Insulin‐Sensitizing Activity |
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| WU Ying-Hua, XIA Bing. Synthesis of (S)‐2‐Ethoxy‐3‐Phenylpropanoic Acid Derivatives and Their Insulin‐Sensitizing Activity[J]. Chinese Journal of Chemistry, 2007, 25(3): 265-267. DOI: 10.1002/cjoc.200790052 |
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| Authors: | WU Ying-Hua XIA Bing |
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| Affiliation: | a.Department of Pharmaceuticals, Huaihua Medical College, Huaihua, Hunan 418000, China ; b. College of Chemistry and Environmental Science, Guizhou University for Nationalities, Guiyang, Guizhou 550025, China |
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| Abstract: | A series of (S)‐2‐ethoxy‐3‐phenylpropanoic acid derivatives were synthesized and their insulin‐sensitizing activities were evaluated in 3T3‐L1 cells. Compounds 1b , 1d , 1e and 1f exhibited more potent insulin‐sensitizing activity than rosiglitazone. |
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| Keywords: | (S)‐2‐ethoxy‐3‐phenylpropanoic acid derivative type 2 diabetes insulin‐sensitizing agent |
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