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Liquidambar styraciflua: a renewable source of shikimic acid |
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| Authors: | Liza B Enrich Ashley Mohadjer Chrystal F Eller Michael Fujinaka |
| Institution: | a Joint Science Department of Claremont McKenna, Pitzer, and Scripps Colleges, W.M. Keck Science Center, 925 N. Mills Avenue, Claremont, CA 91711, USA b College of Pharmacy, University of Arizona, 1703 E. Mabel, PO Box 210207, Tucson, AZ 85721, USA c Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA d Department of Chemistry, Randolph-Macon College, Ashland, VA 23005, USA |
| Abstract: | An isolation procedure is presented that yields 2.4-3.7% w/w pure shikimic acid from the seeds of Liquidambar styraciflua (Sweetgum). Shikimic acid, the starting material in the commercial synthesis of the antiviral agent oseltamivir and an important intermediate in the biosynthesis of aromatic amino acids in plants, was found by HPLC to be abundant in the granular, aborted seeds (6.5% w/w) while present only in small amounts in the developed, fertile seeds (0.14% w/w). This extraction technique makes L. styraciflua, which is found in 40 states of the continental US, a potential renewable source of this important natural product. |
| Keywords: | Liquidambar styraciflua Shikimic acid Plant natural products |
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