Copper triflate/t-BuOOAc-catalyzed amidation of allylic and benzylic acetates with sulfonamides |
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Authors: | David A. Powell Guillaume Pelletier |
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Affiliation: | Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Québec, Canada H9H 3L1 |
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Abstract: | A copper triflate/t-BuOOAc-catalyzed amidation of allylic and benzylic acetates has been developed which is suitable for the coupling of a wide variety of functionalized sulfonamide nucleophiles with acetate electrophiles. The methodology allows for the amidation of benzylic substrates which are not further activated by an additional adjacent alkene or alkyne, enabling simple allylic acetates and primary benzylic acetates to be used as reaction partners. |
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Keywords: | Copper Amidation Sulfonamide Allylic acetate Benzylic acetate |
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