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Crystallography-independent determination of ligand binding modes
Authors:Orts Julien  Tuma Jennifer  Reese Marcel  Grimm S Kaspar  Monecke Peter  Bartoschek Stefan  Schiffer Alexander  Wendt K Ulrich  Griesinger Christian  Carlomagno Teresa
Affiliation:1. Department of NMR‐based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 G?ttingen (Germany);2. Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse, 69117 Heidelberg (Germany), Fax: (+49)?6221‐387‐8519;3. Department of Chemical and Analytical Sciences/Structural Biology, Sanofi‐Aventis Deutschland GmbH, R&D CAS Structural Biology FFM, Industriepark Hoechst, Bldg. G877, 65926 Frankfurt am Main (Germany)
Abstract:
Keywords:drug design  kinases  ligand binding  NMR spectroscopy  pharmacophore mapping
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