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Identification of a 4H-benz[f]indole by-product from the friedel-crafts-based synthesis of benzoylpyrrole calcium channel activators |
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| Authors: | Edward W Huber Robert J Barbuch Christopher R Dalton John M Kane Nelson L Velayo |
| Abstract: | 9,9a-Dihydro-2,9a-dimethyl-4-oxo-4H-benzf]indole-3-carboxylic acid, methyl ester was formed in varying amounts from the Friedel-Crafts-based synthesis of benzoylpyrrole calcium channel activators. The structure of this by-product was determined using two-dimensional long-range 1H-13C heteronuclear correlated and INADEQUATE nmr techniques. |
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