Degradation of Cephaloridine on Alkaline Hydrolysis |
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Authors: | Bartolom Vilanova,Francisco Mu oz,Josefa Donoso,Francisco Garcia-Blanco |
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Affiliation: | Bartolomé Vilanova,Francisco Muñoz,Josefa Donoso,Francisco Garcia-Blanco |
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Abstract: | A kinetic study on the alkaline hydrolysis of cephaloridine ( 1 ) at pH 10.5 and 37° was carried out using ion-pair reversed-phase HPLC. The main resulting degradation products, the 7-epimer 2 of 1 , the Δ2-isomer 3 of 1 , and the 3-methylidene compound 4 were identified. The presence of a pyridinio group at C(31) results in a slightly increased formation constant for the 3-methylidene compound 4 and the 7-epimer 2, and introduces a new reaction: the isomerization of the double bond at C(3) in the dihydrothiazine ring to C(2). |
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