‘One-Pot’ Synthesis of Raumacline from Ajmaline

For the alkaloid raumacline ( 2 ), which is a biotransformation product of ajmaline ( 1 ) in Rauwolfia serpentina cell cultures, an efficient ‘one-pot’ synthesis was developed using a NaBH₄/riboflavin/light-mediated transformation of 1 into 2 with a total yield of 86%.