Acridine derivatives. V. Synthesis and P388 antitumor activity of the novel 9-anilino-2,3-ethylenedioxyacridines |
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Authors: | Michio Kimura Ichizo Okabayashi Akira Kato |
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Abstract: | A new class of deoxyribonucleic acid (DNA)-intercalating antitumor agents, novel 9-anilino-2,3-ethylenedioxyacridines (five compounds) have been synthesized and evaluated for activity against P388 leukemia in vivo. A few of them possessed the same potency of antitumor activity as amsacrine (m-AMSA) which is an important antitumor agent in clinical use. |
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