Natural product chemistry. Part 159. Two methods for the synthesis of 4-azaacronycine as a potential antitumor agent

Two different methods for the synthesis of 4-azaacronycine ( 10 ) have been described. One route with a fusion reaction between 1,3-dihydroxy-10-methyl-9(10H)-acridinone ( 1 ) and 2-amino-2-methyl-3-butyne in a glass ampoule and the other by a reaction of 3-amino-1-methoxy-10-methyl-9(10H)-acridinone ( 9 ) with 2-chloro-2-methyl-3-butyne.