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NMR studies of carrier-mediated transport across lipid bilayer membranes |
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| Institution: | 1. Institute for Glyco-core Research (iGCORE), Gifu University, Gifu 501-1193, Japan;2. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8507, Japan;3. Membrane Cooperativity Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Onna-son, Okinawa 904-0495, Japan;1. Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA 92647, USA;2. Laboratory of Ion Channels, Biological Membranes and Cell Signaling, Department of Biophysics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay |
| Abstract: | Two theoretical models are presented which show how the various kinetic steps involved in transport across lipid bilayer membranes affect NMR spectral lineshapes and relaxation times. The first model applies whenever the transported material moves across the membrane by restricted diffusion. The second model applies when the motion can be described as a jump between membrane interfaces. Both carrier-mediated and carrier-independent cases are treated. Special attention is given to the effects of relaxation in the membrane and to morphology. Exact analytical solutions for the simplest one-dimensional geometry are presented. More complicated morphologies are best treated numerically. |
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