Synthesis of novel glycopeptide-polyoxazoline block copolymers by direct coupling between living anionic and cationic polymerization systems

A novel glycopeptide-containing block copolymer, polyO-(tetra-O-acetyl-β-D -glucopyranosyl)-L -serine]-block-poly(2-methyl-2-oxazoline) ( 5 ), was synthesized by mutual termination of living polymerizations of a sugar-substituted α-amino acid N-carboxyanhydride (NCA) ( 1 ) and 2-methyl-2-oxazoline ( 3 ). 5 was deacetylated to provide the glycopeptide-polyoxazoline block copolymer, polyO-(β-D -glucopyranosyl)-L -serine]-block-poly(2-methyl-2-oxazoline) ( 6 ).