An efficient and chemoselective deprotection of aryl- and styrenyldithioketals (acetals) |
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Authors: | Eng-Chi Wang Shih-Chang Chien Yueh-Hsiung Kuo |
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Affiliation: | a Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan b Department of Chemistry, National Taiwan University, Taipei 106, Taiwan c Center for Food and Biomolecules, National Taiwan University, Taipei 106, Taiwan d Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan e Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan |
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Abstract: | In this Letter, an efficient and chemoselective deprotection of aryl- and styrenyldithioketals (acetals) is described. After being carefully examined, 10% Pd/C and Amberlite 120 in refluxing methanol was found to be an excellent condition for the chemoselective deprotection of aryl- and styrenyldithioketals (acetals) in good yields. Under this condition, no deprotection and no reduction of alkyldithioketals (acetals) was observed. |
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Keywords: | Deprotection Aryldithioketals Palladium on charcoal Amberlite IR-120 |
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