Framework Nucleic Acids for Cell Imaging and Therapy

Over the past decade, structural DNA nanotechnology has been well developed to be a promising and powerful technique to generate various nanostructures with programmability, spatial organization and biocompatibi-lity. With the advent of computer-aided tools, framework nucleic acids have been employed in a series of biomedical applications, ranging from biosensing, bioimaging, diagnosis, to therapeutics. In this review, we summarized recent advances in the construction of precisely assembled DNA nanostructures, and DNA-engineered biomimetics. We also outlined the challenges and opportunities for the translational applications of framework nucleic acids.