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Application of computed tomography images in the evaluation of magnetic nanoparticles biodistribution |
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| Authors: | Argleydson Leão Dias Ronaldo Savarino Levenhagen |
| Institution: | a Área de Ciências Tecnológicas, Centro Universitário Franciscano, Rua dos Andradas, 1614, CEP 97010-032, Santa Maria, RS, Brazil b Universidade de São Paulo, Instituto de Física, Cidade Universitária, CEP 05508-900, São Paulo, SP, Brazil c Universidade Federal de Sao Paulo, Rua Arthur Ridel, 275 Jardim Eldorado, CEP 09941-510, Diadema, SP, Brazil |
| Abstract: | In this work we evaluate the effectiveness of computed tomography images as a tool to determine magnetic nanoparticle biodistribution over biological tissues. For this purpose, tomography images for magnetic nanoparticles, composed of Fe3O4, coated with 2,3-dimercaptosuccinic acid (DMSA), were generated at several material concentrations. The comparison of CT numbers, calculated from these images generated at clinical conditions, with typical CT numbers for biological tissues, shows that the detection of nanoparticle in most tissues is only possible for high material concentrations. |
| Keywords: | Magnetic nanoparticle Computed tomography Imaging contrast Iodine |
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