Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortex |
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Authors: | Joanne?Mayer Michelle?G?Hamel Email author" target="_blank">Paul?E?GottschallEmail author |
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Institution: | (1) Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, 33612-4799 Tampa, Florida, USA |
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Abstract: | Background Brevican is a member of the lectican family of aggregating extracellular matrix (ECM) proteoglycans that bear chondroitin
sulfate (CS) chains. It is highly expressed in the central nervous system (CNS) and is thought to stabilize synapses and inhibit
neural plasticity and as such, neuritic or synaptic remodeling would be less likely to occur in regions with intact and abundant,
lectican-containing, ECM complexes. Neural plasticity may occur more readily when these ECM complexes are broken down by endogenous
proteases, the ADAMTSs (a
disintegrin and metalloproteinase with thrombospondin motifs), that selectively cleave the lecticans. The purpose of these experiments was to determine whether the production
of brevican or the ADAMTS-cleaved fragments of brevican were altered after deafferentation and reinnervation of the dentate
gyrus via entorhinal cortex lesion (ECL). |
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Keywords: | |
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