CLEARANCE TIMES OF PORPHYRIN DERIVATIVES FROM MICE AS MEASURED BY in vivo FLUORESCENCE SPECTROSCOPY |
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| Authors: | J C Kennedy P Nadeau Z J Petryka R H Porrier G Weagle |
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| Institution: | Department of Oncology and Pathology, Queen's University, Kingston, Ontario, Canada K7L 3N6;Department of Chemistry and Chemical Engineering, The Royal Military College of Canada, Kingston, Ontario, Canada K7K 5LO;Porphyrin Products, Inc., P.O. Box 31, 195 South 700 West, Logan UT 84321, USA;Department of Urology, Queen's University, Kingston, Ontario, Canada K6L 3N6 |
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| Abstract: | Abstract
The clearance times of 17 different porphyrin derivatives from SKH:HR-1 mice have been measured using the technique of in vivo fluorescence spectroscopy. This technique monitors the in vivo porphyrin fluorescence observed from the external skin surface. Most hydrophilic porphyrin derivatives show relatively short clearance times, in the order of 2.5–6 h. The dicarboxylic acid porphyrins, proto-, hydroxyethylvinyldeutero-and hematoporphyrin IX have clearance times of 7.8, 12.2 and 14.7 h respectively. The mixture hematoporphyrin derivative has an intermediate clearance time of 12.6 h. N -methylated porphyrins show clearance times in the vicinity of 15–22 h. Monoaspartyl chlorin e6 shows the longest clearance time of all porphyrin derivatives measured (30.3 h). |
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