Base-base interactions in the minor groove of double-stranded DNA |
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| Authors: | Wu Tongfei Nauwelaerts Koen Van Aerschot Arthur Froeyen Matheus Lescrinier Eveline Herdewijn Piet |
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| Institution: | Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. |
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| Abstract: | A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A-T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair. |
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