Cobalt-catalyzed intramolecular [2 + 2 + 2] cocyclotrimerization of nitrilediynes: an efficient route to tetra- and pentacyclic pyridine derivatives |
| |
Authors: | Chang Hong-Tai Jeganmohan Masilamani Cheng Chien-Hong |
| |
Institution: | Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. |
| |
Abstract: | reaction: see text] In this paper, we wish to report the intramolecular 2 + 2 + 2] cocyclotrimerization of nitrilediynes catalyzed by the CoI2(dppe)/Zn system at 80 degrees C in CH3CN. Under these reaction conditions, various highly substituted nitrilediynes having steric conjunction at the alpha and beta positions to a nitrile group and a bulkier substitution at the terminal carbon of alkyne undergo 2 + 2 + 2] cocylotrimerization to afford tetra- and pentacyclic pyridine derivatives in good to excellent yields. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|