Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions |
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| Authors: | Fischer Michael Kählig Hanspeter Schmid Walther |
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| Affiliation: | Department of Organic Chemistry, University of Vienna, W?hringerstrasse 38, 1090 Vienna, Austria. |
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| Abstract: | An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by (19)F-NMR. |
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