A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles |
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Authors: | Lin Xufeng Mao Zhenjun Dai Xixiang Lu Ping Wang Yanguang |
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Institution: | Department of Chemistry, Zhejiang University, Hangzhou 310027, China. lxfok@zju.edu.cn |
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Abstract: | Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benzg]indole. |
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