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A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles
Authors:Lin Xufeng  Mao Zhenjun  Dai Xixiang  Lu Ping  Wang Yanguang
Institution:Department of Chemistry, Zhejiang University, Hangzhou 310027, China. lxfok@zju.edu.cn
Abstract:Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benzg]indole.
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