Molecular design based on 3D pharmacophores. Applications to 5-HT7 receptors |
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| Authors: | Lepailleur Alban Bureau Ronan Lemaître Stéphane Dauphin François Lancelot Jean-Charles Contesse Vincent Lenglet Sébastien Delarue Catherine Vaudry Hubert Rault Sylvain |
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| Affiliation: | Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, 5 rue Vaubénard, 14032 Caen, France. |
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| Abstract: | A definition of a pharmacophore for the 5-HT7 antagonists was carried out by searching the common chemical features of selective antagonists from the literature. A molecular design is described by analyzing the differences between this new pharmacophore and three other 3D serotonin pharmacophores previously described. This comparison led to the synthesis of a new series of potent 5-HT7 antagonists. |
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