Toward mechanized peptide synthesis via polymeric reagents approach |
| |
Authors: | Meir Stern Rami Kalir Abraham Patchornik Abraham Warshawsky Mati Fridkin |
| |
Affiliation: | 1. Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
|
| |
Abstract: | Simultaneous application of high-molecular-weight active esters and polyvinylN,N- diethylbenzylamine was used as a basis for a continuous peptide synthesis via the polymeric reagents approach. Using the synthetic procedure developed, the hexapeptide Boc-L-Pro-L-Val-L-Lys[Z(p-NO2)]-L-Val-L-Tyr(Dnp)-L-Pro-OBzr1 and the tetrapeptide Boc-l-Lys[Z(p-NO2)]-L-Lys[Z(p-NO2)]-L-Arg(NO2)-L-Arg(NO2)-OBzr, corresponding to residues 19–24 and 15–18 of human ACTH, were synthesized in 63 and 70% overall yields, respectively. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|