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Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis |
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| Authors: | Crielaard Bart J Rijcken Cristianne J F Quan Lingdong van der Wal Steffen Altintas Isil van der Pot Martin Kruijtzer John A W Liskamp Rob M J Schiffelers Raymond M van Nostrum Cornelus F Hennink Wim E Wang Dong Lammers Twan Storm Gert |
| Institution: | Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. |
| Abstract: | Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models. |
| Keywords: | drug delivery glucocorticoids micelles nanomedicine rheumatoid arthritis |
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