Iron(I) in Negishi cross-coupling reactions |
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Authors: | Adams Christopher J Bedford Robin B Carter Emma Gower Nicholas J Haddow Mairi F Harvey Jeremy N Huwe Michael Cartes M Ángeles Mansell Stephen M Mendoza Carla Murphy Damien M Neeve Emily C Nunn Joshua |
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Affiliation: | School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK. |
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Abstract: | Herein we demonstrate both the importance of Fe(I) in Negishi cross-coupling reactions with arylzinc reagents and the isolation of catalytically competent Fe(I) intermediates. These complexes, [FeX(dpbz)(2)] [X = 4-tolyl (7), Cl (8a), Br (8b); dpbz = 1,2-bis(diphenylphosphino)benzene], were characterized by crystallography and tested for activity in representative reactions. The complexes are low-spin with no significant spin density on the ligands. While complex 8b shows performance consistent with an on-cycle intermediate, it seems that 7 is an off-cycle species. |
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