Concise formal synthesis of the bryostatin southern hemisphere (C17-C27) |
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| Authors: | Voight Eric A Roethle Paul A Burke Steven D |
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| Institution: | Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1396, USA. |
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| Abstract: | An efficient synthesis of Hale and co-workers' C17-C27 bryostatin southern hemisphere intermediate has been accomplished in six steps and 33% overall yield from (R)-2-(benzyloxy)propanal. The synthesis features a one-pot DIBALH/HWE ester homologation as well as a novel acetonide rearrangement/glycal formation cascade. |
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